Analysis of carbonyl reductase function -development of the new molecular target therapy-

羰基还原酶功能分析-新型分子靶向治疗的开发-

• 批准号: 23592452
• 负责人: MURAKAMI Akihiro
• 金额: $ 3.33万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592452/
• 关键词: carbonyl reductase; 上皮間葉転換; 子宮体癌; 上皮涵養転換; 分子標的治療; 浸潤・転移

Suppression of CBR1 promoted cell proliferation, cell invasion activities, and induced epithelial mesenchymal transition (EMT) in vitro. The tumor volume and weight in CBR1 suppression group were large compared with those in the control group in vivo. The numbers of tumor associated macrophages (TAMs) in stromal tissues was high compared with those in the control group. Therefore, suppression of CBR1 promotes cell invasion activities in vitro by induction of EMT process and cell proliferation activities in vitro and in vivo. Furthermore, suppression of CBR1 may suppress anti-tumor effect and promote pro-tumor effect on TAM. Over-expression of CBR1 has a possibility to be a new molecular target therapy for endometrial cancers.

体外实验表明，抑制CBR1可促进细胞增殖、细胞侵袭活性并诱导上皮间充质转化（EMT）。体内CBR1抑制组肿瘤体积和重量均大于对照组。与对照组相比，间质组织中肿瘤相关巨噬细胞（tumor associated macrophages, tam）数量增多。因此，抑制CBR1通过诱导体外和体内的EMT过程和细胞增殖活性来促进体外细胞的侵袭活性。此外，抑制CBR1可能抑制TAM的抗肿瘤作用，促进TAM的促肿瘤作用。过表达CBR1有可能成为子宫内膜癌新的分子靶向治疗方法。

项目成果

Suppression of carbonyl reductase expression enhances malignant behavior in uterine squamous cell carcinoma : Crabonyl reductase predicts prognosis and lymph node metastasis

抑制羰基还原酶的表达会增强子宫鳞状细胞癌的恶性行为：Crabonyl还原酶可预测预后和淋巴结转移

• 发表时间: 2012
• 期刊: Cancer Lett
• 影响因子: 9.7
• 作者: Murakami A;Fukushima C;Yoshidomi K;Sueoka K;Nawata S;Yokoyama Y;Tsuchida S,Ismail E;Al-Mulla F;Sugino N
• 通讯作者: Sugino N

Decreased expression of carbonyl reductase is a

羰基还原酶表达减少是

• 发表时间: 2011
• 作者: 池田悠至;織田克利 他;Murakami A
• 通讯作者: Murakami A

子宮頸癌におけるcarbonyl reductase1の発現低下が予後不良となるメカニズムの解明

阐明宫颈癌中羰基还原酶1表达降低导致预后不良的机制

• 发表时间: 2013
• 作者: Kuhn E;Wu RC;Guan B;Wu G;Zhang J;Wang Y;Song L;Yuan X;Wei L;Roden RB;Kuo KT;Nakayama K;Clarke B;Shaw P;Olvera N;Kurman RJ;Levine DA;Wang TL;Shih I;村上 明弘
• 通讯作者: 村上 明弘

Suppression of carbonyl reductase 1 promotes tumorigenesis and tumor-associated macrophage migration by induction of epithelial mesenchymal transition

抑制羰基还原酶 1 通过诱导上皮间质转化促进肿瘤发生和肿瘤相关巨噬细胞迁移

• 发表时间: 2012
• 作者: Fujimoto T;Andoh T;Sudo T;Fujita I;Moritake H;Sugimoto T;Sakuma T;Akisue T;Kawabata S;Kirihata M;Suzuki M;Sakurai Y;Ono K;Fukumori Y;Kurosaka M;Ichikawa H;Akihiro MURAKAMI
• 通讯作者: Akihiro MURAKAMI

子宮体癌においてcarbonyl reductaseの低下が予後不良となる機序の解明

阐明羰基还原酶水平降低导致子宫内膜癌预后不良的机制

• 发表时间: 2012
• 作者: 織田 克利;上原 ゆり子;細川 さつき 他;村上明弘
• 通讯作者: 村上明弘