Analysis of carbonyl reductase function -development of the new molecular target therapy-

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Suppression of CBR1 promoted cell proliferation, cell invasion activities, and induced epithelial mesenchymal transition (EMT) in vitro. The tumor volume and weight in CBR1 suppression group were large compared with those in the control group in vivo. The numbers of tumor associated macrophages (TAMs) in stromal tissues was high compared with those in the control group. Therefore, suppression of CBR1 promotes cell invasion activities in vitro by induction of EMT process and cell proliferation activities in vitro and in vivo. Furthermore, suppression of CBR1 may suppress anti-tumor effect and promote pro-tumor effect on TAM. Over-expression of CBR1 has a possibility to be a new molecular target therapy for endometrial cancers.