Effect of microgravity on the gene expression in the mouse vestibular organ

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In the microgravity environment, significant decrease of vestibular inputs cause motion sickness. In this study, we compare the gene expression between 90 days space flight mouse and 15 days space flight mouse and its ground control mouse vestibular. As a result, Oc90, a major component of otoconia expression increased after 15 days space flight, but decreased after 90 days space flight. Similar situation were observed in the calcium binding protein S100a8 and S100a9. These results clearly indicated that the adaptation for micro gravity environment has acute adaptation phase and chronic adaptation phase.