Mucosal immunity in the upper respiratory tract
Mucosal immunity in the upper respiratory tract
批准号:
23592512
负责人:
SUZUKI MASASHI
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
The efficacy of alpha-galactosylceramide (aGalCer) as a mucosal adjuvant was examined. Mice were immunized intranasally with nontypeable Haemophilus influenzae (NTHi) P6 protein and a-GalCer. P6-specific antibody responses in the form of P6-specific IgA in nasal washes and serum IgG titers were significantly elevated. Splenic CD4+ T cells expressed P6-specific Th1 and Th2 cytokine mRNA. In addition, NTHi was quantified in nasal washes following NTHi challenges, and the clearance of NTHi from the nasopharynx was also enhanced. These results indicate that aGalCer might be an effective mucosal adjuvant.
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Nasal immunization with plasmid DNA encoding P6 protein and immunostimulatory complexes elicits nontypeable Haemophilus influenza-specific long term mucosal immune responses in the nasopharynx
使用编码 P6 蛋白的质粒 DNA 和免疫刺激复合物进行鼻免疫可在鼻咽部引发不可分型的流感嗜血杆菌特异性长期粘膜免疫反应
DOI:
--
发表时间:
2011
期刊:
Vaccine
影响因子:
5.5
作者:
[Kodama S, Hirano T, Noda K, Umemoto S, Suzuki M]
通讯作者:
Suzuki M
Th17 cells contribute to nontypeable Haemophilus influenzae-specific protective immunity induced by nasal vaccination with P6 outer membrane protein and a-galactosylceramide
Th17 细胞有助于通过鼻部接种 P6 外膜蛋白和 a-半乳糖神经酰胺诱导的不可分型流感嗜血杆菌特异性保护性免疫
DOI:
--
发表时间:
2011
期刊:
Microbiol Immunol
影响因子:
2.6
作者:
[Noda K, Kodama S, Umemoto S, Nomi N, Hirano T, Suzuki M]
通讯作者:
Suzuki M
Monophosphoryl lipid A induced innate immune responses via TLR4 to enhance clearance of nontypeable Haemophilus influenzae and Moraxella catarrhalis fron the nasopharynx in mice
单磷酰脂质 A 通过 TLR4 诱导先天免疫反应,增强小鼠鼻咽部不可分型流感嗜血杆菌和卡他莫拉菌的清除
DOI:
--
发表时间:
2011
期刊:
FEMS immunol Med Microbiol
影响因子:
--
作者:
[Hirano T, Kodama S, Kawano T, Maeda K, Suzuki M]
通讯作者:
Suzuki M
上気道粘膜免疫におけるNKT細胞の機能解析
NKT细胞在上呼吸道黏膜免疫中的功能分析
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[梅本真吾, 児玉悟, 野田謙二, 鈴木正志]
通讯作者:
鈴木正志
NKT細胞による上気道粘膜免疫応答の解析
NKT细胞上呼吸道粘膜免疫应答分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[梅本真吾, 児玉悟, 野田謙二, 鈴木正志]
通讯作者:
鈴木正志
共 16 条
Physiological and pathophysiological significance of NBCn2 in luminal acid secretion in proximal tubules.
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批准号:18K08201
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2018
-
负责人:SUZUKI MASASHI
-
依托单位:
Monophosphoryl lipid A enhances nontypeable Haemophilus influenzae-specific mucosal and systemic immune responses by intranasal immunization
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批准号:26462585
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2014
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负责人:SUZUKI MASASHI
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依托单位:
The Microscope and 18th- to 19th-Century British Culture
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批准号:22520263
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:2010
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负责人:SUZUKI MASASHI
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依托单位:
海外基金