Role of serine/arginine-rich protein kinase in the formation of choroidal neovascularization

富含丝氨酸/精氨酸的蛋白激酶在脉络膜新生血管形成中的作用

• 批准号: 23592547
• 负责人: SAITO Wataru
• 金额: $ 3.33万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592547/
• 关键词: 眼細胞生物学; 滲出型加齢黄斑編成; 脈絡膜血管新生; 血管内皮増殖因子; SR蛋白質リン酸化酵素; 滲出型加齢黄斑変性; 加齢黄斑変性; VEGF選択的スプライシング; SRPK

Age-related macular degeneration (AMD) is a primary cause of visual loss in developed countries. Recent studies have provided strong evidence that growth factors and cytokines, such as vascular endothelial growth factor (VEGF), play a pivotal role in the process of pathological angiogenesis, choroidal neovascualization (CNV) in AMD. The alternative splicing of VEGF pre-mRNA is regulated by splicing regulatory factors including various serine/arginine-rich (SR) proteins, which are activated by SR protein kinase (SRPK). In this study, we elucidated that a specific inhibitor for SRPK, SRPIN340, attenuates CNV formation in laser-induced CNV model.

在发达国家，年龄相关性黄斑变性（AMD）是视力丧失的主要原因。近年来的研究有力地证明了生长因子和细胞因子，如血管内皮生长因子（VEGF）在AMD的病理性血管生成、脉络膜新生血管化（CNV）过程中起着关键作用。VEGF pre-mRNA的选择性剪接受剪接调节因子的调控，包括各种富含丝氨酸/精氨酸（SR）的蛋白，这些蛋白被SR蛋白激酶（SRPK）激活。在这项研究中，我们阐明了SRPK的特异性抑制剂SRPIN340在激光诱导的CNV模型中减弱了CNV的形成。

项目成果

SRPK阻害薬による脈絡膜血管新生の抑制効果

SRPK抑制剂对脉络膜新生血管的抑制作用

• 发表时间: 2013
• 作者: 董震宇;野田航介;粛藤航;木下哲志;福原淳一;安藤亮;村田美幸;神田敦宏;萩原正敏;石田晋
• 通讯作者: 石田晋

Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization

• 发表时间: 2013-03
• 期刊: Molecular Vision
• 影响因子: 2.2
• 作者: Zhenyu Dong;K. Noda;Atsuhiro Kanda;Junichi Fukuhara;Ryo Ando;M. Murata;W. Saito;M. Hagiwara;S. Ishida

Serine/arginine-rich protein Kinase Blockade attenuates choroidal neovascularization

富含丝氨酸/精氨酸的蛋白激酶阻断减弱脉络膜新生血管形成

• 发表时间: 2013
• 作者: 藤川恵子;井上馨;越山隆恵;山岸麗子;相原一;Zhenyu Dong;Dong Z,Noda K,Kanda A,Fukuhara J,Ando R,Murata M,Saito W,Hagiwara M,Ishida S
• 通讯作者: Dong Z,Noda K,Kanda A,Fukuhara J,Ando R,Murata M,Saito W,Hagiwara M,Ishida S