A chemokine receptor as a novel treatment target of age-related macular degeneration,
A chemokine receptor as a novel treatment target of age-related macular degeneration,
批准号:
23592552
负责人:
YANAGI Yasuo
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
本研究探讨炎症细胞因子IP-10对年龄相关性黄斑变性所致脉络膜新生血管的影响。结果表明IP-10在炎症巨噬细胞和视网膜色素上皮细胞中产生,并通过其受体CXCR 3抑制脉络膜新生血管形成。本研究为老年性黄斑变性(一种导致法律的失明的毁灭性疾病)确定了一个新的治疗靶点。
英文摘要
This study investigated the effects of inflammatory cytokine, IP-10, on choroidal neovascularization due to age-related macular degeneration. The results demonstrated that IP-10 is produced in the inflammatory macrophage and retinal pigment epithelial cells and inhibits choroidal neovascularization through its receptor, CXCR3.This study identified a new treatment target for age-related macular degeneration, a devastating condition leading to legal blindness.
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DOI:
10.1167/iovs.11-8232
发表时间:
2012-04-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Fujimura, Shigeto, Takahashi, Hidenori, Yanagi, Yasuo]
通讯作者:
Yanagi, Yasuo
Role of lipofuscin on retinal pigment epithelial cells and Bruch's membrane
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批准号:21791669
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:YANAGI Yasuo
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依托单位:
海外基金