A chemokine receptor as a novel treatment target of age-related macular degeneration,

趋化因子受体作为年龄相关性黄斑变性的新治疗靶点，

• 批准号: 23592552
• 负责人: YANAGI Yasuo
• 金额: $ 3.41万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592552/
• 关键词: 加齢黄斑変性; ケモカイン; CXCR3; 脈絡膜新生血管

This study investigated the effects of inflammatory cytokine, IP-10, on choroidal neovascularization due to age-related macular degeneration. The results demonstrated that IP-10 is produced in the inflammatory macrophage and retinal pigment epithelial cells and inhibits choroidal neovascularization through its receptor, CXCR3.This study identified a new treatment target for age-related macular degeneration, a devastating condition leading to legal blindness.

本研究探讨炎性细胞因子IP-10对老年性黄斑变性所致脉络膜新生血管的影响。结果表明，IP-10在炎性巨噬细胞和视网膜色素上皮细胞中产生，并通过其受体CXCR3抑制脉络膜新生血管。这项研究确定了一种新的治疗目标，用于治疗老年性黄斑变性，这是一种导致法定失明的毁灭性疾病。

项目成果

Angiostatic Effect of CXCR3 Expressed on Choroidal Neovascularization

• DOI: 10.1167/iovs.11-8232
• 发表时间: 2012-04-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Fujimura, Shigeto;Takahashi, Hidenori;Yanagi, Yasuo
• 通讯作者: Yanagi, Yasuo