Role of Oct3/4 in retinal development and dieseases

我们试图研究Oct3/4基因在正常视网膜和包括肿瘤在内的视网膜疾病中的作用。在第一步中，我们重新研究了Oct3/4在小鼠眼睛中的表达。我们从正常小鼠视网膜中分离到一种新的Oct3/4变异体，它受翻译调控。利用人视网膜母细胞瘤和其他癌细胞株，我们检测了Oct3/4转录本的表达，并鉴定了各种新的转录本。我们的结果显示了小鼠和人类Oct3/4基因变体表达的明显差异，为了解Oct3/4在体细胞组织中的功能提供了有用的相关信息。

We tried to investigate roles of Oct3/4 gene during development of normal retina and retinal diseases including tumors. At the first step, we re-investigated Oct3/4 expression in mouse eye. We isolated a novel Oct3/4 variant from normal mouse retina, which is regulated under translational control. Using human retinoblastoma and other carcinoma cell lines, we tested the expression of Oct3/4 transcripts and identified a variety of novel ones. Our results showed the clear different pattern between mice and human Oct3/4 gene variants expression, providing available relevant information for understanding the function of Oct3/4 in somatic tissue.