Development of implantable volitional controlled electrical stimulation device for treatment of facial paralysis

为了治疗面瘫，我们的主要目标是开发意志控制的植入式功能性电刺激装置。优化了电路设计，使植入过程最小化。为此，探索皮下植入装置的供电方式。特别是非接触式充电系统，在实验设置中被瞄准但最终失败。另一方面，我们通过动物实验模型和临床病例，探讨了神经残端远端在游离神经血管肌移植中对移植肌段神经支配的作用。实验和临床证实了该方法的实用性。

For the treatment of established facial paralysis, we primary aimed to develop volitional controlled implantable functional electrical stimulation device. Design of electrical circuit which is minimized for implantation was optimised. Therefore, way of electrical supply to subcutaneously implanted device was searched. Especially non-touching charging system was aimed but fialed in the experimental settings. On the other hand, we investigated the utility of distal side of nerve stump for the innervation of transplanted muscle segment during free neurovascular muscle transfer with animal experimental model and clinical cases. The utility was confirmed both experimentally and clinically.