Development of new medical materials using polyphosphoric acid

在过去的十年里，人们发现多聚磷酸被广泛用作食品添加剂，影响各种细胞的生物活性。因此，为了开发使用聚磷酸的新型医用材料，我们检测了聚磷酸钠(Poly-P)对牙髓(DP)细胞增殖和分化的影响。结果表明，在低浓度条件下，Poly-P可显著促进DP细胞的增殖并诱导其向成牙本质细胞分化。我们目前的研究结果提示，Poly-P诱导的基质金属蛋白酶-3可能参与了细胞的增殖。

For the past decade, it has been found that polyphosphoric acid used widely as a food additive affects the bioactivity of various cells. Therefore, for the development of new medical materials using the polyphosphoric acid, we examined effects of the sodium polyphosphate (Poly-P) on the proliferation and differentiation of dental pulp (DP) cells. As a result, Poly-P significantly accelerated the proliferation of DP cells and induced their differentiation into odontoblasts with low concentration. Our current data suggests that matrix metalloproteinase (MMP) -3 induced by Poly-P may be involved in the cell proliferation.