Biofunctionalization of titanium oral implant by DLC coating and chemical modifications.

通过 DLC 涂层和化学修饰对钛口腔种植体进行生物功能化。

• 批准号: 23592895
• 负责人: ENDO Kazuhiko
• 金额: $ 3.24万
• 依托单位: Health Sciences University of Hokkaido
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592895/
• 关键词: 口腔インプラント; DLCコーティング; 化学修飾; 耐食性; 細胞適合性; ぬれ性; 細胞付着; 細胞増殖; 抗菌性; DLC膜; 生体親和性; 純チタン; 生体活性化

The present study was aimed to develop a novel titanium implant with high durability and biofunctionality by coating DLC film together with chemical surface modifications. The corrosion resistance of the titanium in acidic fluoride solution was significantly improved by coated DLC film using the PBIID method, suggesting that the DLC coatings prevent surface roughness due to corrosion. It was also suggested that chemical modifications of the DLC coated titanium with cell adhesive proteins or antibacterial molecule was effective in producing the oral titanium implant with improved biofunctionalities such as high cytocompatible and antibacterial properties.

本研究旨在通过涂覆DLC膜和化学表面修饰来开发一种具有高耐久性和生物功能性的新型钛种植体。钛在酸性氟化物溶液中的耐腐蚀性显著提高，表明类金刚石涂层防止了表面因腐蚀而产生的粗糙度。用细胞黏附蛋白或抗菌分子对DLC涂层的钛进行化学修饰，可以有效地制备出具有高细胞相容性和抗菌性能等生物学功能的口腔钛种植体。

项目成果

Corrosion resistance of diamond-like carbon-coated titanium in fluoride solutions

类金刚石碳涂层钛在氟化物溶液中的耐腐蚀性能

• 发表时间: 2012
• 作者: K. Endo;M. Iijima;M. Hashimoto;F. Nagano;Y. Ida;H. Toshima;I. Mizoguchi
• 通讯作者: I. Mizoguchi

Frictional and mechanical properties of diamond-like carbon-coated orthodontic brackets

• DOI: 10.1093/ejo/cjr113
• 发表时间: 2013-04-01
• 期刊: EUROPEAN JOURNAL OF ORTHODONTICS
• 影响因子: 2.6
• 作者: Muguruma, Takeshi;Iijima, Masahiro;Mizoguchi, Itaru
• 通讯作者: Mizoguchi, Itaru

Evaluation of MC3T3-E1 responses to DLC-coated titanium

评估 MC3T3-E1 对 DLC 涂层钛合金的响应

• 发表时间: 2014
• 作者: A. B. Dithi;H. Toshima;Y. Ida;F. Nagano-Takebe;K. Endo
• 通讯作者: K. Endo

DLC膜をコーティングした純チタンの疑似体液中における腐食挙動

镀DLC膜纯钛在模拟体液中的腐蚀行为

• 发表时间: 2012
• 作者: 遠藤一彦;飯嶋雅弘;井田有亮;橋本正則;長野二三;戸島洋和、溝口到
• 通讯作者: 戸島洋和、溝口到