Effects of oxidative stress to pathogenesis of cleft palate.

氧化应激对腭裂发病机制的影响。

• 批准号: 23592926
• 负责人: YAMADA Tomohiro
• 金额: $ 3.16万
• 依托单位: Kyushu University (2013)Kochi University (2011-2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592926/
• 关键词: 口蓋裂; 酸化ストレス; 口蓋骨; 軟口蓋; TCDD

To examine effect of the oxidative stress in the cleft palate pathogenesis, some oxidative stress inducers, i.e. TCDD, steroid, LPS, and D-galactosamine, were administered to pregnant mice. As a result, it was thought that palatogenesis was not received much effect by the oxidative stress only within the dam (liver in particular). Therefore TCDD administration mice were used as oxidative stress model. Because underexpression of osteogenesis-related protein and the myoblastic differentiation marker was observed, it was suggested that TCDD can induce cleft palate by dehiscence after the palate union with osteo-, and myogenesis suppression, in addition by the mechanism of palatal fusion inhibition.

为探讨氧化应激在腭裂发病机制中的作用，对妊娠小鼠给予TCDD、类固醇、脂多糖和D-氨基半乳糖等氧化应激诱导剂。因此，人们认为只有在DAM(特别是肝脏)内的氧化应激对腭裂的发生没有太大的影响。因此，采用TCDD染毒小鼠作为氧化应激模型。由于成骨相关蛋白和成肌细胞分化标记物的低表达，提示TCDD除通过抑制腭部融合的机制外，还可能通过与成骨细胞结合后的裂开和肌肉形成的抑制来诱导腭裂。

项目成果

TCDD disrupts posterior palatogenesis and causes cleft palate.

• DOI: 10.1016/j.jcms.2013.01.024
• 发表时间: 2014
• 期刊: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
• 作者: Tomohiro Yamada;A. Hirata;E. Sasabe;T. Yoshimura;Seiji Ohno;N. Kitamura;Tetsuya Yamamoto

TCDDによる口蓋後部の形成異常と口蓋裂発症との関わり

TCDD导致的后腭畸形与腭裂发育的关系

• 发表时间: 2013
• 作者: 山田朋弘;平田あずみ;井村英人;大野清二;笹部衣里;仙頭慎哉;村田智子;北村直也;山本哲也
• 通讯作者: 山本哲也