Detection of carcinoma cells in peripheral circulation by oncolgtic virus therapy

通过肿瘤病毒治疗检测外周循环中的癌细胞

• 批准号: 23592944
• 负责人: KAMATANI Takaaki
• 金额: $ 3.33万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592944/
• 关键词: 口腔癌; 扁平上皮癌; ウイルス増殖; 口腔扁平上皮癌; テロメライシン; E1遺伝子

In this study, we investigated the detection of peripheral circulating tumor cells by an adenovirus included the GFP gene and the hTERT gene infected to oral carcinoma cells in circulating tumor cell model. Although we could confirm fluorescence in oral carcinoma cells, there were no relation between fluorescence and mRNA expression or protein expression. These results indicated that oral carcinoma cells would be circulate in peripheral blood flow in a certain period.

在本研究中，我们研究了检测外周循环肿瘤细胞的腺病毒包括绿色荧光蛋白基因和hTERT基因感染口腔癌细胞在循环肿瘤细胞模型。虽然我们可以证实在口腔癌细胞的荧光，荧光和mRNA表达或蛋白质表达之间没有关系。提示口腔癌细胞在一定时间内可在外周血循环中循环。