Detection of carcinoma cells in peripheral circulation by oncolgtic virus therapy

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In this study, we investigated the detection of peripheral circulating tumor cells by an adenovirus included the GFP gene and the hTERT gene infected to oral carcinoma cells in circulating tumor cell model. Although we could confirm fluorescence in oral carcinoma cells, there were no relation between fluorescence and mRNA expression or protein expression. These results indicated that oral carcinoma cells would be circulate in peripheral blood flow in a certain period.