Overexpression of the atypical protein kinase C rambda/iota in oral squamous cell carcinoma is associated with degrees of malignancy

口腔鳞状细胞癌中非典型蛋白激酶 C rambda/iota 的过度表达与恶性程度相关

• 批准号: 23592972
• 负责人: KOIZUMI Toshiyuki
• 金额: $ 3.24万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592972/
• 关键词: 口腔扁平上皮癌; aPKCλ/ι; Cancer stem cell; IL-6; 口腔がん

Atypical protein kinase C lambda/iota (aPKC lambda/iota) is a cell polarity-regulating protein and is localized in the tight junction or apical membrane in the epithelial cell. Previous studies suggested that aPKC lambda/iota over-expression and abnormal localization were involved in tumor progression in some cancers. We investigated the correlation between the aPKC lambda/iota expression pattern and the clinicopathological parameters in oral squamous cell carcinoma (OSCC) cases immunohistochemically, and evaluated the utility of aPKC lambda/iota expression pattern as a biomarker for the degree of malignancy.As a result, we found immunostaining for aPKC lambda/iota was more intense in poorly differentiated OSCC, compared with moderately- and well- differentiated cases. In addition, cases of younger ages showed intense immunostaining for aPKC lambda/iota than in older. These results suggest that aPKC lambda/iota overexpression might be useful to predict the clinical outcomes of OSCC.

非典型蛋白激酶C λ/i ota（aPKC λ/i ota）是一种细胞极性调节蛋白，定位于上皮细胞的紧密连接或顶膜。以往的研究表明，aPKC λ/iota的过度表达和异常定位参与了一些癌症的肿瘤进展。我们通过免疫组织化学方法研究了口腔鳞状细胞癌（OSCC）中aPKC λ/iota表达模式与临床病理参数之间的关系，并评估了aPKC λ/iota表达模式作为恶性程度生物标志物的实用性。此外，年轻患者的aPKC λ/iota免疫染色强度高于老年患者。这些结果表明，aPKC λ/iota过表达可能有助于预测OSCC的临床结局。

项目成果

口腔扁平上皮癌におけるaPKC λ/ι過剰発現の臨床病理学的意義

aPKC λ/ι过表达在口腔鳞状细胞癌中的临床病理意义

• 发表时间: 2011
• 作者: 重石英生;奥井岳;小野重弘;Andra Rizqiawan;東川晃一郎;杉山勝,鎌田伸之;馬場隼一，足立 誠，岩井俊憲，小栗千里，小泉敏之，來生 知，廣田 誠，光藤健司，藤内 祝
• 通讯作者: 馬場隼一，足立 誠，岩井俊憲，小栗千里，小泉敏之，來生 知，廣田 誠，光藤健司，藤内 祝

進行口腔癌に対する逆行性超選択的動注化学放射線療法 上顎歯肉扁平上皮癌(T3、4)に対する治療効果の検討

逆行超选择性动脉内灌注放化疗治疗晚期口腔癌（T3、4）的疗效观察。

• 发表时间: 2013
• 期刊: 頭頸部癌
• 作者: 小泉 敏之;光藤 健司;小栗 千里;岩井 俊憲;光永 幸代;飯坂 友宏;來生 知;廣田 誠;近津 大地;藤内 祝
• 通讯作者: 藤内 祝