Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

STR/ort 小鼠颞下颌关节自发发生骨关节炎

• 批准号: 23593004
• 负责人: HAMADA Yoshiki
• 金额: $ 3.33万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593004/
• 关键词: 変形性顎関節症; STR/Ortマウス; 顎関節OA; STR/Ort マウス

TMJs from 11 STR/ort mice euthanized at 30, 40, 50, 60, or 70 weeks of age, and from six CBA mice euthanized at 30, 40, or 60 weeks of age were examined. Toluidine blue and tartrate-resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using micro-computed tomography. At the age of 40 to 50 weeks, 66% of STR/ort mice losed of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by micro-computed tomography. The STR/ort mouse strain appears to be developed spontaneous osteoarthritis-like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis.

11只在30、40、50、60、70周龄被安乐死的STR/ort小鼠和6只在30、40、60周龄被安乐死的CBA小鼠的TMJs被检测。甲苯胺蓝和抗酒石酸酸性磷酸酶染色用于评估关节软骨的组织学变化。使用显微计算机断层扫描评估TMJ关节软骨的形态学变化。40 ~ 50周龄时，66%的STR/ort小鼠关节软骨组织学上缺失，暴露骨出现空化和侵蚀，髁突形状逐渐改变。此外，通过显微计算机断层扫描观察骨关节炎的形态学改变和结构改变。STR/ort小鼠品系似乎随着年龄的增长在TMJ发生自发性骨关节炎样病变，可能是研究TMJ骨关节炎发病机制的有用模型。

项目成果

Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice International Journal of Oral & Maxillofacial Surgery

STR/ort 小鼠颞下颌关节自发发生骨关节炎 国际口腔杂志

• 发表时间: 2014
• 作者: Kenichi Kumagai;Satsuki Suzuki;Kanri;Yoriaki;Keisuke Fujii;Masahiro Wake;Ryuji Suzuki;and Yoshiki Hamada
• 通讯作者: and Yoshiki Hamada

STR/Ortマウスにおける変形性顎関節症モデルとしての有用性について

关于 STR/Ort 小鼠作为颞下颌关节骨关节炎模型的有用性

• 发表时间: 2011
• 作者: Nathaphon Tangjit;Toyohisa Kusakabe;Junichiro Iida;熊谷賢一,鈴木さつき,藤井恵介,鈴木隆二,濱田良樹
• 通讯作者: 熊谷賢一,鈴木さつき,藤井恵介,鈴木隆二,濱田良樹