Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

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TMJs from 11 STR/ort mice euthanized at 30, 40, 50, 60, or 70 weeks of age, and from six CBA mice euthanized at 30, 40, or 60 weeks of age were examined. Toluidine blue and tartrate-resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using micro-computed tomography. At the age of 40 to 50 weeks, 66% of STR/ort mice losed of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by micro-computed tomography. The STR/ort mouse strain appears to be developed spontaneous osteoarthritis-like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis.