Energy metabolism in human masseter muscle observed by mfMRI and 31P-MRS

mfMRI和31P-MRS观察人体咬肌能量代谢

• 批准号: 23593032
• 负责人: KITAHARA TORU
• 金额: $ 3.16万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593032/
• 关键词: 咀嚼筋; 疲労; 筋機能MRI; 31P-MRS; 咀嚼筋疲労; MRS; T2値

1. T2 mapping of the individual masseter muscles showed that 30% MVC produces significant increases in the values. The T2 relaxation time decreased rapidly after the contraction. 2. Using 31P-MRS, it was observed that muscle activation produced significant decreases in the signal intensity of phosphocreatine (PCr), leading to recovery after releasing the 30% MVC, while the inorganic phosphate level (Pi) showed moderate increases and returned to its former condition.The current state of investigation indicates that the mechanism responsible for the increased T2 results from osmotically-driven shifts in the muscle water that increase the volume of the intracellular space, and from intracellular acidification. Both mfMRI and MRS, a quantitative noninvasive biochemical sampling technique, represent viable alternatives for metabolic studies of the masseter muscle.These findings suggested the effectiveness of both mfMRI and 31P-MRS as promising tools to study masseter muscle fatigue.

1.个体咬肌T2标测结果显示，30%的MVC可使咬肌的T2值显著增加。收缩后T2松弛时间迅速缩短。2.用~(31)P-MRS观察到，肌肉激活后磷酸肌酸(PCr)信号强度显著降低，释放30%MVC后恢复，而无机磷水平(PI)适度升高，并恢复到原来的状态。目前的研究表明，T2增加的机制是渗透压驱动的肌肉水分变化增加细胞内空间体积，以及细胞内酸化。MfMRI和MRS(一种定量的非侵入性生化采样技术)都是研究咬肌代谢的可行选择。这些发现表明mfMRI和31P-MRS都是研究咬肌疲劳的有效工具。

项目成果

咬筋における筋疲労と浮腫性変化の関連に関する研究

肌肉疲劳与咬肌水肿变化关系的研究

• 发表时间: 2013
• 期刊: 日本口腔診断学会総会プログラム・抄録集
• 作者: 佐々城真;飯久保正弘;下里舞;笹野高嗣
• 通讯作者: 笹野高嗣

フイルムレスペーパーレスのセファロメトリックプレディクション

无胶片无纸头影测量预测

• 发表时间: 2012
• 期刊: 顎変誌
• 作者: Tanne K;Yoshioka M;et al.;北原亨
• 通讯作者: 北原亨