Energy metabolism in human masseter muscle observed by mfMRI and 31P-MRS

mfMRI和31P-MRS观察人体咬肌能量代谢

• 批准号: 23593032
• 负责人: KITAHARA TORU
• 金额: $ 3.16万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593032/
• 关键词: 咀嚼筋; 疲労; 筋機能MRI; 31P-MRS; 咀嚼筋疲労; MRS; T2値

1. T2 mapping of the individual masseter muscles showed that 30% MVC produces significant increases in the values. The T2 relaxation time decreased rapidly after the contraction. 2. Using 31P-MRS, it was observed that muscle activation produced significant decreases in the signal intensity of phosphocreatine (PCr), leading to recovery after releasing the 30% MVC, while the inorganic phosphate level (Pi) showed moderate increases and returned to its former condition.The current state of investigation indicates that the mechanism responsible for the increased T2 results from osmotically-driven shifts in the muscle water that increase the volume of the intracellular space, and from intracellular acidification. Both mfMRI and MRS, a quantitative noninvasive biochemical sampling technique, represent viable alternatives for metabolic studies of the masseter muscle.These findings suggested the effectiveness of both mfMRI and 31P-MRS as promising tools to study masseter muscle fatigue.

1。T2映射单个咬合肌肉表明，30％MVC的值显着增加。收缩后T2松弛时间迅速减少。 2。使用31p-MRS，观察到肌肉激活在释放30％MVC后导致磷酸酸（PCR）的信号强度显着降低，从而导致恢复，而无机磷酸盐水平（PI）表现出适度的增加并恢复到了先前的状态，表明了对水域的增加，从而使脉冲的脉络量增加了TT2的脉冲状态。细胞内空间和细胞内酸化。 MFMRI和MRS是一种定量的非侵入性生化抽样技术，代表了咬肌的代谢研究的可行替代方法。这些发现表明，MFMRI和31P-MRS的有效性是研究群众肌肉疲劳的有前途的工具。

项目成果

咬筋における筋疲労と浮腫性変化の関連に関する研究

肌肉疲劳与咬肌水肿变化关系的研究

• 发表时间: 2013
• 期刊: 日本口腔診断学会総会プログラム・抄録集
• 作者: 佐々城真;飯久保正弘;下里舞;笹野高嗣
• 通讯作者: 笹野高嗣

フイルムレスペーパーレスのセファロメトリックプレディクション

无胶片无纸头影测量预测

• 发表时间: 2012
• 期刊: 顎変誌
• 作者: Tanne K;Yoshioka M;et al.;北原亨
• 通讯作者: 北原亨