Effects of early life stress on transcription or translation of developmental brain nerve cells

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It is not clear about mechanism of pathogenic mechanism of mental disorder including autism. The purpose of this study is to elucidate the relation between early stress exposure and epigenetic gene regulations in the brain. It is also another purpose to explore the possibility that these epigenetic gene regulations exert influence to growth of brain development.There are some reports that early life events can induce long lasting changes in physiology and behavior.We chose Mother infant separation as early life stress.This separation starts from one day after birth for one week or two weeks.Corticosteron in the blood was measured. There was no significant difference between two groups.After this, we started another separation and total RNA samples of mesencephalon were prepared in seventh day after birth.New target genes were explored with DNA methylation and micro array. We did not get unique target genes.