Development of new resin seal in wound healing using activation of innate immunity.

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The present study investigated whether vitamin D affect the promotion of wound healing, and the resistance to bacterial infection as chemical barriers in oral epithelium. Expression of antimicrobial peptides in epithelial keratinocyte cells were upregulated by the stimulation with vitamin D, indicating that vitamin D induced keratinocyte differentiation and barrier function. Wound healing of the rat oral mucosa was promoted to apply ointment supplementation of vitamin D. The results indicate that the application of vitamin D is efficacious of the wound healing and the barrier function in oral epithelium.