Analysis of patients with gingival hyperplasia and hypertrichosis

近年来研究发现组织蛋白酶活性与牙龈增生的发生有关。据报道，一些牙龈增生患者有严重的增生。因此，本研究的目的是评估牙龈增生和增生患者和健康人的成纤维细胞的组织蛋白酶活性，患者的细胞显示组织蛋白酶-L活性降低，组织蛋白酶-B活性升高。此外，Cathepsin-L基因敲除小鼠的毛囊翻转异常，提示Cathepsin活性降低可能与毛囊增生的发生有关。

Recently, it has revealed that Cathepsin activities can invole with the onset of gingival hyperplasia. And some gingival hyperplasia patients are reported to have severe hypertrichosis. Therefore, the purpose of this study is to evaluate cathepsin activities of fibroblasts from patients with gingival hyperplasia and hypertrichosis and healthy person.The patients' cells showed decrease in Cathepsin-L activities, and increase in Cathepsin-B activities. Furthermore, Cathepsin-L knockout mice have abnormal turn over of hair follicle.From these results, it is suggested that decreased activity of Cathepsin may play a role to onset of hypertrichosis.