Analysis of the condition stress on the periodontal disease

香烟中的尼古丁使牙周韧带纤维胚细胞产生应激反应蛋白-嗜铬粒蛋白a （CgA）。特别是，与主动吸烟相比，被动吸烟条件下较高CgA的表达水平增加。我们认为压力可能参与了牙周组织的反应。我们对CgA添加组细胞周期的相关基因簇进行了功能分析。添加CgA组细胞生长因子、MAPK和Smad基因组升高。在牙周韧带内注射低浓度CgA，观察病程，未见组织改变。

Nicotine in a cigarette smoke makes a production of stress-responsive protein chromogranin A(CgA) due to periodontal ligament fibers blast cells increase.Particularly, expression levels of higher CgA increased under a passive smoking condition as compared with an active smoking.We suggested the possibility that stress was involved in a response of the periodontium.We conducted the functional analysis of the associated gene cluster for a cell cycle in the CgA addition group. The group additioned of CgA increased cell growth factor, MAPK and Smad gene group. We injected low-concentrated CgA into periodontal ligament, and we observed course, but the tissue changes was not found.