The influence on bone marrow cells of the indoor environment chemicals: Analysis of dendritic cell differentiation and the Treg induction

室内环境化学物质对骨髓细胞的影响：树突状细胞分化和Treg诱导分析

• 批准号: 23601027
• 负责人: SUGIURA Tsutomu
• 金额: $ 3.49万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23601027/
• 关键词: 室内環境化学物質; 制御性T細部; 骨髄由来細胞; STAT5; 胎児期暴露; 転写因子; 胸腺細胞; ホルムアルデヒド; 骨髄細胞; 胎児期曝露; 次世代影響; 樹状細胞; Treg

As it has been reported that exposure of a wide variety of chemical substances to the child was increased, we investigated the effect of a substance chemical, such as formaldehyde and toluene, which is suspected in particular the effect of chemical prenatal period. From consideration of the exposure model mice, thymocytes immediately prepared from exposed mice after birth. Additionally, bone marrow derived cells were also highly activated.Thus, the low concentration chemical prenatal exposure affected cellular events on the molecular level.

由于有报道称儿童接触多种化学物质的情况有所增加，我们调查了甲醛和甲苯等化学物质的影响，特别怀疑这是产前时期化学物质的影响。考虑到暴露模型小鼠，出生后立即从暴露小鼠中制备胸腺细胞。此外，骨髓来源的细胞也高度活化，因此，低浓度的化学品产前暴露影响细胞的分子水平上的事件。

项目成果

Intratracheal administration of Asian sand dust induces autophagic and apoptotic phenomena in splenocytes.

气管内施用亚洲沙尘可诱导脾细胞自噬和凋亡现象。

• 发表时间: 2011
• 作者: Song;Y., Yoshida;Y.
• 通讯作者: Y.

Intratracheal administration of Asian sand dust induces autophagic and apoptotic phenomena in splenocytes

气管内施用亚洲沙尘诱导脾细胞自噬和凋亡现象

• 发表时间: 2011
• 作者: Song;Y.;Yoshida;Y.
• 通讯作者: Y.

Developmental stage-specific changes in immunological biomarkers in male C3H/HeN mice after early life toluene exposure

雄性 C3H/HeN 小鼠早期接触甲苯后免疫生物标志物的发育阶段特异性变化

• 发表时间: 2012
• 期刊: Toxicology Letters
• 影响因子: 3.5
• 作者: Win-Shwe TT;Kunugita N;Nakajima D;Yoshida Y;Fujimaki H
• 通讯作者: Fujimaki H

室内環境汚染物質2-エチルヘキサノールの免疫細胞機能に対する影響

室内环境污染物2-乙基己醇对免疫细胞功能的影响

• 发表时间: 2013
• 作者: Tin-Tin Win-Shwe;Naoki Kunugita;Daisuke Nakajima;Yasuhiro Yoshida;Hidekazu Fujimaki.;森田健太郎,吉田安宏ら
• 通讯作者: 森田健太郎,吉田安宏ら

The indoor air pollutant 2-ethyl-hexanol affects immune cells

室内空气污染物2-乙基己醇影响免疫细胞

• 发表时间: 2012
• 作者: Tin-Tin Win-Shwe;Naoki Kunugita;Daisuke Nakajima;Yasuhiro Yoshida;Hidekazu Fujimaki.;森田健太郎,吉田安宏ら;森田健太郎,吉田安宏ら.
• 通讯作者: 森田健太郎,吉田安宏ら.