Fundamental and clinical studies on angiogenesis by vibration therapy: Why does the comfortable vibration promote wound healing?

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Our research group have developed a novel wound healing vibrator. In this study, we investigated the effects and its molecular mechanisms of vibrator on the deep tissue injuries (DTIs) and diabetic foot ulcers, for which the effective intervention have not been established.We investigated the effects of vibration on DTI in the animal study, in which we used a unique model rat for DTI deterioration. We revealed that vibration improved the tissue hypoxia and remarkably attenuated the ulceration of wounds.We conducted a randomized control study in two hospitals in Indonesia (international collaborative research) to reveal the promoting effect of vibration on diabetic foot ulcer. We found the significant decreases of wound area reduction and healing period in the vibration group.