Fundamental and clinical studies on angiogenesis by vibration therapy: Why does the comfortable vibration promote wound healing?

振动疗法血管生成的基础和临床研究：为什么舒适的振动可以促进伤口愈合？

• 批准号: 23612001
• 负责人: NAGASE Takashi
• 金额: $ 3.49万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23612001/
• 关键词: 創傷看護学; 振動; 褥瘡; 糖尿病性足潰瘍; 低酸素; タンパク質分解酵素; 血管新生; 創傷治癒; Deep Tissue Injury; 国際情報交換; インドネシア

Our research group have developed a novel wound healing vibrator. In this study, we investigated the effects and its molecular mechanisms of vibrator on the deep tissue injuries (DTIs) and diabetic foot ulcers, for which the effective intervention have not been established.We investigated the effects of vibration on DTI in the animal study, in which we used a unique model rat for DTI deterioration. We revealed that vibration improved the tissue hypoxia and remarkably attenuated the ulceration of wounds.We conducted a randomized control study in two hospitals in Indonesia (international collaborative research) to reveal the promoting effect of vibration on diabetic foot ulcer. We found the significant decreases of wound area reduction and healing period in the vibration group.

我们的研究小组开发了一种新型的伤口愈合振动器。在本研究中，我们研究了振动器对深层组织损伤（DTIs）和糖尿病足溃疡的影响及其分子机制，目前尚未建立有效的干预措施。我们在动物实验中研究了振动对DTI的影响，我们使用了一种独特的DTI恶化模型大鼠。我们发现振动改善了组织缺氧，显著减轻了伤口溃疡。我们在印度尼西亚的两家医院进行随机对照研究（国际合作研究），揭示振动对糖尿病足溃疡的促进作用。我们发现振动组的伤口面积缩小和愈合时间明显减少。

项目成果

New insight in etiology of deep tissue injury

深部组织损伤病因学的新见解

• 发表时间: 2012
• 作者: Nagase T;Sanada H;Nakagami G;Minematsu T;Sari Y;Sugama J
• 通讯作者: Sugama J

Vibration attenuates the deterioration of deep tissue injury.

振动可以减轻深层组织损伤的恶化。

• 发表时间: 2012
• 作者: Sari Y;Minematsu T;Nakagami G;Nagase T;Oe M;Mori T;Sugama J;Sanada H;Tamio Hoshika;Sari Y
• 通讯作者: Sari Y

Activation of MMP-2 and MMP-9 during Deterioration of Deep Tissue Injury in Rats

大鼠深部组织损伤恶化过程中 MMP-2 和 MMP-9 的激活

• 发表时间: 2011
• 作者: Sari Y;Minematsu T;Nakagami G;Akase T;Nagase T;Oe M;Mori T;Sugama J;Sanada H
• 通讯作者: Sanada H

Vibration attenuates the deterioration of deep tissue injury

振动减轻深层组织损伤的恶化

• 发表时间: 2012
• 作者: Sari Y;Minematsu T;Nakagami G;Nagase T;Oe M;Mori T;Sugama J;Sanada H
• 通讯作者: Sanada H

Chapter 3, Nursing Biology. In, Bioengineering Nursing : New horizons of nursing research (Sanada H, Mori T & Nagase T, Eds)

第 3 章，护理生物学。

• 发表时间: 2014
• 作者: Minematsu T;Tamai N;Nishijima Y
• 通讯作者: Nishijima Y