Clarification of Endothelial Cells' Response to Flow Force andInclined Centrifugal Force

血管内皮细胞对血流的反应机制对于阐明循环系统疾病的发生、发展机制以及开发新的治疗和预防方法具有重要意义。在这项研究中，我们提出了一种新的实验方法来研究内皮细胞对机械刺激的反应。比较了细胞对离心力和常规流体力刺激的反应。实验结果为内皮细胞切应力传感的位置提供了有用的信息。

Mechanism of endothelial cells' response to blood flow is crucial for clarification of the mechanism of occurrence and development of circulatory diseases and development of new treatment and prevention methods. In this research we proposed a new experimental methodology to investigate the endothelial cells' response to mechanical stimulation. The cells' response to the centrifugal force was compared with those to the conventionalflow force stimulation. The experimental results provide useful information on the location of shear stress sensing in endothelial cells.