Integrative Analysis of Structure and Extracellular Environment in Disuse Atrophic Skeletal Muscle

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Currently our country is facing a serious problem that the super-aging society. It is quite ideal that all elder people spend their life without being suffering from any physical and social discomfort. However, number of elder people have poor activity of daily life due to disuse syndrome, due to aging, paralysis with cerebral vascular diseases, chronic obstructive pulmonary disease, sarcopenia with fracture, congestive heart failure, and so on. Muscle atrophy is a condition that occurs not only in elder people, but also young healthy people in case of astronauts who is exposed to the microgravity environment, and cast immobilization due to fracture. Thus, it is important to reveal the mechanism of muscle atrophy and mechanical properties of atrophied muscle. In this study, we performed experiments of passive transvers stiffness of muscle cells with an atomic force microscope and x-ray diffraction of muscle tissue in synchrotron radiation facility.