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Method to evaluate accurate response waveforms of cardiovascular system to external perturbations and its application to healthcare supports system

心血管系统对外界扰动准确响应波形评估方法及其在医疗支持系统中的应用

基本信息

批准号：
23650415
负责人：
KOTANI Kiyoshi
金额：
$ 2.41万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

项目摘要

It is important to evaluate the response of the cardiovascular system to external stimuli for understanding homeostasis. However, the response should be distorted by the conventional time domain analysis when a frequency of the effect of external stimuli matches that of intrinsic fluctuations. The purpose of this study is to propose a mixed signal processing of time domain and respiratory phase domain to extract the response waveforms of heartbeat and blood pressure (BP) to external stimuli and to clarify the reaction mechanisms of the cardiovascular system.First, cardiovascular responses to swallowing are investigated. Sudden tachycardia and changes of blood pressure is accurately extracted and evaluated. Second, responses to postural changes investigated. It is confirmed that there is dispersion between systolic and diastolic blood pressure as their response waveforms. Third, application to detect startling is tested and the accuracy of the detection is improved using cardiovascular response.In conclusion, the proposed method accurately evaluates response waveforms to external stimuli from the cardiovascular system in the time domain and enable for physiologicalconsiderations. The method would be applicable to several daily-life situations such as prevention of orthostatic syncope and startling detections.

评估心血管系统对外界刺激的反应对于了解体内平衡是很重要的。然而，当外部刺激作用的频率与内部起伏的频率匹配时，传统的时间域分析应该使响应失真。本研究的目的是提出一种基于时间域和呼吸相域的混合信号处理方法来提取心率和血压对外界刺激的响应波形，以阐明心血管系统对外界刺激的反应机制。对突发性心动过速和血压变化进行准确提取和评估。第二，对姿势变化的反应进行了调查。证实了收缩压和舒张压之间存在频散作为其响应波形。第三，测试了检测惊吓的应用程序，并利用心血管反应提高了检测的准确性。总之，该方法在时间域上准确地评估了心血管系统对外部刺激的响应波形，并使生理学考虑成为可能。该方法将适用于几种日常生活情况，如预防直立性晕厥和令人震惊的检测。