Method to evaluate accurate response waveforms of cardiovascular system to external perturbations and its application to healthcare supports system

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It is important to evaluate the response of the cardiovascular system to external stimuli for understanding homeostasis. However, the response should be distorted by the conventional time domain analysis when a frequency of the effect of external stimuli matches that of intrinsic fluctuations. The purpose of this study is to propose a mixed signal processing of time domain and respiratory phase domain to extract the response waveforms of heartbeat and blood pressure (BP) to external stimuli and to clarify the reaction mechanisms of the cardiovascular system.First, cardiovascular responses to swallowing are investigated. Sudden tachycardia and changes of blood pressure is accurately extracted and evaluated. Second, responses to postural changes investigated. It is confirmed that there is dispersion between systolic and diastolic blood pressure as their response waveforms. Third, application to detect startling is tested and the accuracy of the detection is improved using cardiovascular response.In conclusion, the proposed method accurately evaluates response waveforms to external stimuli from the cardiovascular system in the time domain and enable for physiologicalconsiderations. The method would be applicable to several daily-life situations such as prevention of orthostatic syncope and startling detections.