The ferritin independent antioxidant mechanism in intestinal mucosaof iron deficient rats.

在铁缺乏大鼠的小肠中，谷胱甘肽（GSH）的浓度保持较高的铁充足的大鼠相比。我们发现铁蛋白非依赖性抗氧化机制可能抑制铁缺乏大鼠脂肪的过氧化。缺铁组大鼠结扎后肠粘膜细胞内活性铁库增加。补铁可降低缺铁和补铁大鼠脑组织GSH含量，但缺铁组下降幅度较大。当GSH合成抑制剂降低肠粘膜总GSH浓度时，缺铁组和铁充足组的脂肪氧化均被铁加速。

In the small intestine of iron deficient rats, glutathione (GSH) concentrations were maintained highly as compared with iron sufficient rats. We found that the ferritin independent-antioxidant mechanism might inhibit adipose hyperoxidation in iron deficientrats. When iron was given to the ligated intestinal tract, labile iron pool in mucosal cells was rose in iron deficient group. GSH concentration was decreased by iron administration in both iron sufficient and deficient rats, but the rate of decline was bigger in iron deficient group. When total GSH concentration of intestinal mucosa was reduced by synthetic inhibitor of the GSH, adipose oxidation by iron was accelerated both in the iron deficient and sufficient groups.