The ferritin independent antioxidant mechanism in intestinal mucosaof iron deficient rats.

缺铁大鼠肠粘膜铁蛋白独立抗氧化机制。

• 批准号: 23650485
• 负责人: SHINODA Shoko
• 金额: $ 2.41万
• 依托单位: Tokyo Metropolitan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650485/
• 关键词: 食と栄養; 鉄欠乏; GSH; 酸化ストレス; 過剰鉄; labile iron pool; フェリチン; 小腸; グルタチオン; TBARS

In the small intestine of iron deficient rats, glutathione (GSH) concentrations were maintained highly as compared with iron sufficient rats. We found that the ferritin independent-antioxidant mechanism might inhibit adipose hyperoxidation in iron deficientrats. When iron was given to the ligated intestinal tract, labile iron pool in mucosal cells was rose in iron deficient group. GSH concentration was decreased by iron administration in both iron sufficient and deficient rats, but the rate of decline was bigger in iron deficient group. When total GSH concentration of intestinal mucosa was reduced by synthetic inhibitor of the GSH, adipose oxidation by iron was accelerated both in the iron deficient and sufficient groups.

在缺铁大鼠的小肠中，谷胱甘肽（GSH）浓度与铁充足大鼠相比保持较高水平。我们发现铁蛋白独立抗氧化机制可能抑制铁缺乏症患者的脂肪过度氧化。结扎小肠给予铁后，缺铁组粘膜细胞内不稳定铁池增加。铁足、缺铁组大鼠GSH浓度均降低，但缺铁组下降幅度更大。当合成GSH抑制剂降低肠黏膜总GSH浓度时，铁缺乏组和铁充足组的脂肪氧化均加速。

项目成果

貧血ラット十二指腸におけるフェリチン非依存的抗酸化メカニズム

贫血大鼠十二指肠中铁蛋白独立的抗氧化机制

• 发表时间: 2012
• 作者: 山本真智子;篠田卓弥;団未那美;篠田粧子
• 通讯作者: 篠田粧子

鉄の腸管吸収調節-鉄摂取の最適濃度を探る-

肠道对铁吸收的调节 - 探索铁摄入的最佳浓度 -

• 发表时间: 2013
• 作者: Do;H. T. V.;Y. Ide;Mugo;A. N.;Yagi;T.;八木年晴;篠田粧子
• 通讯作者: 篠田粧子

Effect of Shimotsuto (Si-Wu-Tang; Chinese herbal medicine traditionally used in Japan) with/without iron administration on iron deficient rats.

Shimotsuto（四物汤；日本传统使用的中草药）加/不加铁剂对缺铁大鼠的影响。

• 发表时间: 2013
• 作者: Mugo A.N.;Kobayashi J.;Mikami B.;Ohnishi K.;Yagi T.;Shinoda S and Chen F
• 通讯作者: Shinoda S and Chen F