Analysis of the ability for memory-learning from a stand point of nutrrhythm and its basic research for prevention of senile dementia

通过被动回避实验（PAT）和Morris水迷宫实验，研究了高脂肪（HF）饮食对时钟突变小鼠（clock）和野生小鼠（wild）学习记忆功能的影响。结果表明，除了饲喂正常饮食的时钟小鼠外，饲喂HF饮食的野生雌性小鼠对PAT的保留能力也受到损害。很明显，雌性小鼠在记忆保持方面更容易受到HF饮食的影响，并且外周昼夜节律的干扰对于维持小鼠的学习和记忆功能至关重要。

We examined the effect of a high-fat (HF) diet on learning and memory functions in clock-mutant mice (clock) comparing its wild mice (wild) by measuring passive avoidance test (PAT) and by using Morris Water Maze apparatus. In the results, not only clockmice fed on the control diet, but also wild female mice fed on the HF diet were impaired the retention for PAT. It became obvious that female mice, with respect to memory retention, are more susceptible to HF diet and that entrainment of the peripheral circadian rhythm is essential for maintenance of learning and memory functions in mice.