Establishment the methods of the measurement of human papillomavirus (HPV) vaccine efficacy and the study for its practical use on cervical cancer eradication

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Two kinds of human papillomavirus (HPV) vaccine currently commercialized in Japan are estimated that they would be able to protect approximately 70% of cervical cancer cases. On the other hand, the method of measurement on these HPV vaccine efficacies had not been established yet. In this study, we developed the original methods on measure the neutralized HPV types of 16 and 18 antibodies in sera, types which are known as the most typical high risk factors of cervical cancer, induced by the vaccination. We also practically evaluated pre-/post- vaccinated sera and found that the levels of antibody are certainly increased by HPV vaccine.