Cohort study for colorectal diminutive adenomatous polyps

结直肠小腺瘤性息肉队列研究

• 批准号: 23650632
• 负责人: OTAKE Yosuke
• 金额: $ 2.25万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650632/
• 关键词: 大腸腺腫性ポリープ; 大腸癌; advanced neoplasia; コホート研究; 大腸内視鏡検査; non-referral strategy; 大腸微小腺腫性ポリープ

In this longitudinal study, we assess the incidence of advanced neoplasia detected during follow-up colonoscopies in patients who were found to have diminutive (<5 mm) adenomatous polyps during initial screening colonoscopies but were not referred for removal. Advanced neoplasia was defined as low-grade dysplasia more than 10 mm, adenoma with a high-grade dysplasia component, or carcinoma. Advanced neoplasia was detected in 20 (2.8%; 95% CI 1.6 to 4.0) of 713 such patients during follow-up colonoscopies over a median interval of 61 months. Only one patient with advanced neoplasia needed surgical treatment, however, such lesions in remaining 19 patients were curatively treated by endoscopic resection. Risk of advanced neoplasia was not increased even when diminutive adenomatous polyps had been untreated at screening. Our non-referral strategy was considered to be acceptable, provided such patients undergo recommended follow-up colonoscopies.

在这项纵向研究中，我们评估了在初始筛查结肠镜检查中发现有微小（<5 mm）腺瘤性息肉但未被转诊切除的患者在随访结肠镜检查中发现的晚期肿瘤的发生率。晚期肿瘤定义为低度异型增生超过10 mm，腺瘤伴高度异型增生成分，或癌。在中位间隔61个月的随访结肠镜检查中，713例患者中有20例（2.8%; 95%CI 1.6 - 4.0）检测到晚期肿瘤。只有1例晚期肿瘤患者需要手术治疗，然而，其余19例患者的此类病变均通过内镜切除术治愈。即使筛选时未治疗小型腺瘤性息肉，晚期瘤形成的风险也不会增加。我们的非转诊策略被认为是可以接受的，只要这些患者接受推荐的随访结肠镜检查。

项目成果

大腸がんスクリーニングの現状と展望

结直肠癌筛查现状及展望

• 发表时间: 2012
• 作者: Otake Y;Saito Y;大竹陽介;大竹陽介
• 通讯作者: 大竹陽介

5mm以下大腸ポリープの取り扱い 特に腺腫性ポリープについて

处理小于5毫米的结肠息肉，特别是腺瘤性息肉

• 作者: Otake Y;Saito Y;大竹陽介;大竹陽介;大竹陽介
• 通讯作者: 大竹陽介

Follow-up Study of Small Colonic Polyps <5mm -Japanese Experience-

<5mm小结肠息肉的随访研究-日本经验-

• 发表时间: 2014
• 作者: Otake Y;Saito Y
• 通讯作者: Saito Y

5mm 未満の微小腺腫性ポリープの取扱い-non resect strategy の可能性-

小于 5mm 的微腺瘤性息肉的处理 - 非切除策略的可能性 -

• 发表时间: 2013
• 作者: Otake Y;Saito Y;大竹陽介
• 通讯作者: 大竹陽介