Nucleic acid-metal-organic nanostructure based on nucleic aciddesignability and metal complex functionality

为了实现自下而上的纳米技术的实际应用，需要可设计性和功能性。在这里，我们使用核酸作为可设计的纳米结构支架和金属配合物作为功能材料。特别是，为了在DNA纳米结构上制备金属配合物，我们重点研究了具有大芳香规划表面的g -四联体。发现富含鸟嘌呤的长dna折叠形成串珠结构，使我们有可能设计g -四重阵列。此外，一些阴离子配体如酞菁铜适合特异性结合g -四联体。这些结果使我们能够基于核酸的可设计性和金属配合物的功能来设计核酸-金属-有机纳米结构。

To achieve practical application of bottom-up nanotechnology, designability and functionality are required. Here, we used nucleic acids as designable nanostructure scaffolds and metal complexes as functional materials. Especially, to fabricate metal complexes on DNA nanostructures, we focused on G-quadruplex, which has large aromatic planner surface. It was found that long guanine-rich DNAs fold to form a beads-on-a-string structure, making us possible to design a G-quadruplex array. Moreover, some anionic ligands such as copper phthalocyanine are suitable to bind G-quadruplex specifically. These results allow us to design nucleic acid-metal-organic nanostructure based on nucleic acid designability and metal complex functionality.