Nucleic acid-metal-organic nanostructure based on nucleic aciddesignability and metal complex functionality

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To achieve practical application of bottom-up nanotechnology, designability and functionality are required. Here, we used nucleic acids as designable nanostructure scaffolds and metal complexes as functional materials. Especially, to fabricate metal complexes on DNA nanostructures, we focused on G-quadruplex, which has large aromatic planner surface. It was found that long guanine-rich DNAs fold to form a beads-on-a-string structure, making us possible to design a G-quadruplex array. Moreover, some anionic ligands such as copper phthalocyanine are suitable to bind G-quadruplex specifically. These results allow us to design nucleic acid-metal-organic nanostructure based on nucleic acid designability and metal complex functionality.