A molecular structure-function investigation of major membrane channels involved in olfactory transduction

参与嗅觉转导的主要膜通道的分子结构-功能研究

• 批准号: DP0346317
• 负责人: Em/Prof Peter Barry
• 金额: $ 15.71万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-04-03 至 2007-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0346317
• 关键词: molecular; structure; function; investigation; major

Olfactory receptor neurons are extraordinarily-sensitive sensors for detecting minute concentrations of odorant molecules. This project aims to extend our previous studies of these specialised mammalian olfactory cells by using state-of-the art technologies: electrophysiology (patch-clamp) and molecular biology (site-directed-mutagenesis), to investigate how the molecular structure of their ion channels (selective protein pores) and receptors contribute to the odorant-induced generation of electrical activity, which mediates our sense of smell (olfaction). The project has specific relevance for understanding olfaction, as well as relevance for other sensory systems and other ion channels.

嗅觉感受器神经元是非常敏感的传感器，用于检测微小浓度的气味分子。本项目旨在通过使用最先进的技术：电生理学（膜片钳）和分子生物学（位点定向诱变），扩展我们之前对这些特殊哺乳动物嗅觉细胞的研究，研究它们的离子通道（选择性蛋白质孔）和受体的分子结构如何促进气味诱导的电活动的产生，从而介导我们的嗅觉（嗅觉）。该项目对理解嗅觉，以及其他感觉系统和其他离子通道具有特定的相关性。