Development of chiral nano-space using highly-ordered molecular gel for molecular recognition

利用高度有序的分子凝胶开发手性纳米空间进行分子识别

• 批准号: 23655069
• 负责人: TAKAFUJI Makoto
• 金额: $ 2.58万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23655069/
• 关键词: キラル超分子集合体; 分子認識; 液体クロマトグラフィー; 異性体分離; キラル超分子

Glutamide-derivatives with a triethoxysilyl group (CmGDD) was newly synthesized and confirmed to form fibrous self-assembly in various organic solvents. CmGDD was grafted onto the surface of porous silica particles through siloxane bonds (Sil-CmGDD) for use in reversed-phase HPLC as a stationary phase. Solid-state 13C NMR and DSC measurements indicate that CmGDD can form highly-oriented structures on the silica surface. The Sil-C10GDD packed-column was investigated by retention studies of polycyclic aromatic hydrocarbons. The chromatographic results showed that the Sil-CmGDD provided excellent selectivity for these isomers such as stilbenes and terphenyls than conventional octadecylated silica. It is estimated that these preferable results can be brought about through hydrogen bond-mediated molecular orientation of weak interaction sites such as carbonyl groups. Sil-CmGDD also showed excellent separations of bio-related molecules such as tocopherols isomers and Vitamine Ds.

含三乙氧基硅基的谷氨酰胺衍生物(CmGDD)是一种新合成的化合物，它能在多种有机溶剂中形成纤维状自组装。CmGDD通过硅氧烷键(sIL-CmGDD)接枝到多孔二氧化硅颗粒表面，用于反相高效液相色谱固定相。固体~(13)C核磁共振和DSC测量表明，CmGDD可以在二氧化硅表面形成高度取向的结构。通过对多环芳烃的保留研究，考察了SIL-C10GDD填充柱的性能。层析结果表明，与传统的十八烷基硅胶相比，Sil-CmGDD对二苯乙烯和三苯基等异构体具有良好的选择性。据估计，这些较好的结果可以通过氢键介导的弱相互作用中心的分子取向，如羰基。SIL-CmGDD还显示了对生育酚、异构体和维生素D等生物相关分子的良好分离。

项目成果

パイ共役分子を集積した有機相を用いる高選択的HPLC分離剤の開発

使用具有集成π共轭分子的有机相开发高选择性HPLC分离剂

• 作者: 野口 広貴;高藤 誠;伊原 博隆
• 通讯作者: 伊原 博隆

Separation of Bioactive- and Shape-Constrained Isomers by Molecular Gel Forming Compounds-Grafted Silica in RP-HPLC

在 RP-HPLC 中通过分子凝胶形成化合物-接枝二氧化硅分离生物活性和形状受限的异构体

• 发表时间: 2011
• 作者: Abul K.Mallik;Hongdeng Qiu;Tsuyoshi Sawada;Makoto Takafuj;Hirotaka Ihara
• 通讯作者: Hirotaka Ihara

Self-assembled Molecular Gel Thin Film for Molecular Recognition

用于分子识别的自组装分子凝胶薄膜

• 发表时间: 2012
• 作者: Makoto Takafuji;Thiraporn Charoenraks;Hirotaka Ihara
• 通讯作者: Hirotaka Ihara

Peptide-based surface modified silica particles: adsorption materials for dye-loaded wastewater treatment

• DOI: 10.1039/c3ra43871f
• 发表时间: 2013-10
• 期刊: RSC Advances
• 影响因子: 3.9
• 作者: S. Ray;M. Takafuji;H. Ihara

Molecular orientation of gel forming compounds and their effect on molecular-shape selectivity in liquid chromatography

液相色谱中凝胶形成化合物的分子取向及其对分子形状选择性的影响

• 发表时间: 2014
• 期刊: Journal of Chromatography A
• 影响因子: 4.1
• 作者: Abul K. Mallik;Sudhina Guragain;Hiroshi Hachisako;Mizanur M. Rahman;Makoto Takafuji;Hirotaka Ihara
• 通讯作者: Hirotaka Ihara