The novel mechanism of cancer radioresistance on internal radiation therapy and development of radiosensitizers

本研究通过辐射诱导细胞外ATP释放来探讨辐射抗性的机制，并探讨P2受体抑制剂作为新型辐射增敏剂的可能性。我们发现，经~（13）I标记的抗体处理后，细胞外ATP的释放<131>和P_2Y_6受体参与了辐射抗性。此外，我们还证实了P2Y_6受体抑制剂增强了~（13）I标记抗体对肿瘤细胞的生长抑制作用<131>，提示P2Y_6受体抑制剂是一种新型的放射增敏剂。

In this study, we investigated the mechanism of radioresistance through radiation-induced extracellular ATP release and possibility of P2 receptor inhibitor as a novel radiosensitizer. We found extracellular ATP release after treatment of ^<131>I-labeled antibody and an involvement of P2Y_6 receptor in radioresistance. Moreover, we elucidated that the inhibitor of P2Y_6 receptor enhanced growth inhibition of cancer cells induced by ^<131>I-labeled antibody, suggesting P2Y_6 receptor inhibitor as a novel radiosensitizer.