Immune response to frameshift mutation-derived peptides in microsatellite instability positive pancreatic cancer

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We extracted 100 cases of pancreatic ductal adenocarcinoma from December 2010 to 2013. A dedicated database for the clinicopathological findings was constructed.Microsatellite instability (MSI) status was analyzed in 40 cases in 2011, and in 60 cases in 2012 and 2013. It is considered MSI-positive pancreatic cancer is included in 5-10% of all pancreatic cancer in general. However, all 100 cases were diagnosed as microsatellite stable (MSS). MSI-High could not be detected at all.In this study, we found a case of early pancreatic cancer (PanIN-3; carcinoma in situ). Detailed pathological mapping and immunostaining for the resected specimen was performed. These findings were published in the journal of Clinical Cancer Research.