Study of postoperative portal venous thrombosis after splenectomy in cirrhotic patients and its therapeutic implication

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The aim of study is to elucidate the mechanism of portal venous thrombosis (PVT) after splenectomy in cirrhotic patients. Preoperative study showed that prothrombin time was more prolonged in PVT group than in non PVT group (p=0.0593), and value of antithrombin III was lower in PVT group (p=0.0054). In non PVT group, value of antithrombin III was recovered in a few days after splenectomy, however recovery of antithrombin III was delayed in PVT group after splenectomy and value of antithombin III was significantly lower in PVT group on 7thpostoperative day (p<0.05) than in non PVT group. It is supposed that hypercoagulopathy might be one of causes of PVT after splenectomy due to delayed functional recovery of liver.