Can mTOR become target of the molecular target therapy in esophagus squamous cell carcinoma?

哺乳动物雷帕霉素靶蛋白（mTOR）在调节细胞生长和增殖中起着重要作用。已经在几种类型的癌症中报道了与临床结果相关的mTOR的异常激活。mTOR作为抗癌治疗的潜在靶点越来越重要。然而，食管鳞状细胞癌中mTOR激活的预后特征尚不确定。

The mammalian target of rapamycin (mTOR) plays central roles inthe regulation of cell growth and proliferation. The aberrant activation of mTOR inrelation to clinical outcome has been reported in several types of cancers. mTOR isincreasingly important as a potential target for anticancer therapy. Nonetheless, aprognostic feature of mTOR activation in esophageal squamous cell carcinoma remainsuncertain.