Measurement of pulmonary arterial flow velocity and shear stress using synchrotron radiation pulmonary micro-angiography in pulmonary hypertension

高肺血流量的先天性心脏病常并发不可逆的肺动脉高压。切应力的增加可能在诱导内膜和中膜肥大和增加血管阻力中起关键作用。应用同步辐射微血管造影技术对高流量肺动脉高压大鼠模型进行肺动脉造影，观察肺动脉微血管的形态学变化，并测量肺动脉血流速度。高流量肺动脉高压模型组大鼠肺动脉血流速度明显高于对照组（82.3 ± 8.5mm/sec vs.46.1 ± 4.3mm/sec，P<0.05）。同步辐射微血管造影可测量肺血流速度。这一新发展的技术可能有助于研究与高流量肺动脉高压相关的血管重构机制。

Congenital heart disease with high pulmonary blood flow is frequently complicated by the development of irreversible pulmonary hypertension. Increased shear stress may play a key role to induce intimal and medial hypertrophy and increase vascular resistance. We performed the pulmonary angiography in high flow pulmonary hypertension rat model by using synchrotron radiation micro-angiography to visualize the pulmonary microvasculature and measure the pulmonary flow velocity. The velocity of pulmonary artery in the high flow pulmonary hypertension rat model was significantly increased compared with the control (82.3 plusminus 8.5 mm/sec vs. 46.1 plusminus 4.3 mm/sec, p<0.05). Synchrotron radiation micro-angiography was useful for measuring the pulmonary blood flow velocity. This newly developed technology may help to investigate the mechanism of vascular remodeling associated with high flow pulmonary hypertension.