Significant role of bone marrow derived cells in compensatory regenerative lung growth and wound healing.

骨髓衍生细胞在代偿性再生性肺生长和伤口愈合中发挥重要作用。

• 批准号: 23791571
• 负责人: TANAKA Toshiki
• 金额: $ 2.5万
• 依托单位: 独立行政法人国立病院機構山ロ宇部医療センター (2012)National Hospital Organization,Yamaguchi - Ube Medical Center (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791571/
• 关键词: 呼吸器外科学; 代償性肺再生; 骨髄細胞; 創傷治癒; 骨髄由来幹細胞

After left pneumonectomy, bone marrow-derived cells (BMCs) accumulated in the wound and contributed to tissue repair. This phenomenon was possibly addressed that BMCs was differentiated to myofibroblast and vascular endotjelial cells. BMCs which accumulated in the residual lung parenchyma after left pneumonectomy was possibly differentiated to alveolar cells and vascular endothelial cells, which would contribute to regeneration of lung tissue. BMCs would affect tissue repair during the lug regeneration.

左肺切除术后，骨髓衍生的细胞（BMC）积聚在伤口中并有助于组织修复。这种现象可能是解决了BMC与肌纤维细胞和血管赋予细胞区分开的。左肺切除术后残留肺实质中积累的BMC可能与肺泡细胞和血管内皮细胞区分开，这将有助于肺组织的再生。 BMC会在凸耳再生过程中影响组织修复。

项目成果

手術侵襲による骨髄由来幹細胞の動員および集積が術後創傷治癒に関与する

手术侵袭引起的骨髓干细胞的动员和积累参与术后伤口愈合

• 发表时间: 2012
• 作者: Hara M;Sato M;Takahashi H;Takayama S;Takeyama H;竹本圭宏
• 通讯作者: 竹本圭宏