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Significant role of bone marrow derived cells in compensatory regenerative lung growth and wound healing.

骨髓衍生细胞在代偿性再生性肺生长和伤口愈合中发挥重要作用。

基本信息

批准号：
23791571
负责人：
TANAKA Toshiki
金额：
$ 2.5万
依托单位：
独立行政法人国立病院機構山ロ宇部医療センター (2012)National Hospital Organization,Yamaguchi - Ube Medical Center (2011)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791571/
关键词：
呼吸器外科学代償性肺再生骨髄細胞創傷治癒骨髄由来幹細胞

项目摘要

After left pneumonectomy, bone marrow-derived cells (BMCs) accumulated in the wound and contributed to tissue repair. This phenomenon was possibly addressed that BMCs was differentiated to myofibroblast and vascular endotjelial cells. BMCs which accumulated in the residual lung parenchyma after left pneumonectomy was possibly differentiated to alveolar cells and vascular endothelial cells, which would contribute to regeneration of lung tissue. BMCs would affect tissue repair during the lug regeneration.

左肺切除术后，骨髓源性细胞（BMC）在伤口中积聚并有助于组织修复。这种现象可能是由于 BMC 分化为肌成纤维细胞和血管内皮细胞而得到解决的。左肺切除后残留肺实质中积累的BMCs可能分化为肺泡细胞和血管内皮细胞，这将有助于肺组织的再生。 BMC 会在耳再生过程中影响组织修复。