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Comprehensive analysis of glioma LOH regions using next-generation sequencing

Comprehensive analysis of glioma LOH regions using next-generation sequencing
使用新一代测序对神经胶质瘤 LOH 区域进行综合分析
批准号:
23791608
负责人:
HATA Nobuhiro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
Mutation analyses on patient-derived glioma tissues: IDH1/2 mutations and LOH on 1p, 19q, 10, and 17p were analyzed on 162 patient-derived glioma tissues using conventional capillary sequencer. IDH1 mutant primary GBMs showed distinct clinical specificities. By IDH mutation and 1p/19q LOH analyses, grade III oligodendroglial tumors were divided 3 subtypes showing different clinical outcomes. Comprehensive mutation analysis on glioma cancer stem cells using next-generation sequencer: Four patient-derived GBM sphere cultures were analyzed by amplicon PCR using a Truseq Amplicon Cancer Panel, followed by next-generation sequencing using a Miseq instrument (Illumina). Bioinformatics analysis was performed using 'CLC GenomicsWorkbench' software
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会议论文
Long-term outcome of patients with oligodendroglial tumors treated up-front
少突胶质细胞瘤患者预先治疗的长期结果
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: []
通讯作者:
Long-term outcome of patients with oligodendroglial tumors treated up-front with PAV therapy
预先接受 PAV 治疗的少突胶质细胞瘤患者的长期结果
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [秦 暢宏]
通讯作者: 秦 暢宏
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [秦 暢宏]
通讯作者: 秦 暢宏
Molecular biomarkers of glioblastoma: current targets and clinical implications
胶质母细胞瘤的分子生物标志物:当前目标和临床意义
DOI: --
发表时间: 2012
期刊: Current Biomarker Findings
影响因子: --
作者: [Yoshimoto K, Mizoguchi M, Hata N, et. al.]
通讯作者: et. al.
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