Comprehensive analysis of glioma LOH regions using next-generation sequencing
Comprehensive analysis of glioma LOH regions using next-generation sequencing
批准号:
23791608
负责人:
HATA Nobuhiro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Mutation analyses on patient-derived glioma tissues: IDH1/2 mutations and LOH on 1p, 19q, 10, and 17p were analyzed on 162 patient-derived glioma tissues using conventional capillary sequencer. IDH1 mutant primary GBMs showed distinct clinical specificities. By IDH mutation and 1p/19q LOH analyses, grade III oligodendroglial tumors were divided 3 subtypes showing different clinical outcomes. Comprehensive mutation analysis on glioma cancer stem cells using next-generation sequencer: Four patient-derived GBM sphere cultures were analyzed by amplicon PCR using a Truseq Amplicon Cancer Panel, followed by next-generation sequencing using a Miseq instrument (Illumina). Bioinformatics analysis was performed using 'CLC GenomicsWorkbench' software
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Long-term outcome of patients with oligodendroglial tumors treated up-front
少突胶质细胞瘤患者预先治疗的长期结果
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[]
通讯作者:
Long-term outcome of patients with oligodendroglial tumors treated up-front with PAV therapy
预先接受 PAV 治疗的少突胶质细胞瘤患者的长期结果
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[秦 暢宏]
通讯作者:
秦 暢宏
ダイレクトシークエンス法によるIDH1 mutation解析:グリオーマ126例での検討
直接测序法IDH1突变分析:126例胶质瘤病例研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[秦 暢宏]
通讯作者:
秦 暢宏
Molecular biomarkers of glioblastoma: current targets and clinical implications
胶质母细胞瘤的分子生物标志物:当前目标和临床意义
DOI:
--
发表时间:
2012
期刊:
Current Biomarker Findings
影响因子:
--
作者:
[Yoshimoto K, Mizoguchi M, Hata N, et. al.]
通讯作者:
et. al.
IDH1 /2変異解析簡便化の試み
尝试简化 IDH1/2 突变分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[]
通讯作者:
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