Simultaneous evaluation of the articular cartilage and subchondral bone with photoacoustic microscopy

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Photoacoustics (PA) imaging is the conversion of nano-second pulse lasers to ultrasound (US) by thermal expansion of the material. We evaluated the articular cartilage and subchondral bone with the PA method. It canIn the normal cartilage, low signal intensity was observed in the articular cartilage but high signal intensity in the cancellous bones in PA imaging. In the OA cartilage, higher signal intensity was observed in the articular cartilage and subchondral bone in PA imaging, which might indicate an increase of blood flow of them.