Development of a method of enhancing antitumor drug delivery byextracellular environment control

本研究结果表明，骨肉瘤、肺癌和胃癌细胞暴露于复杂的肿瘤微环境（即高静水压、缺氧、酸性和低营养）中，能够控制自身的细胞生长和侵袭转移能力，从而在这种严重的肿瘤微环境条件下生存。另一方面，光动力疗法可整合多种细胞因子的释放，使恶性肿瘤的光敏剂吖啶橙放大，并通过对微小肿瘤的控制，增强细胞毒效应。

The results of this study showed that osteosarcoma, lung cancer and gastric cancer cells which exposed to the complex tumor micro-environment (i.e. high hydrostaticpressure, hypoxic, acidic and low nutrition) controlled their own cell growth and invasiveness and metastasis ability to survie in such severe tumor micro-environmental condition. On the other hand, the release of various cytokines for survive can be integrated to amplify acridine orangewhich is a photosensitizer for malignant tumors, and the contol of micro-tumor environmentenhance the cytotoxic effects by photodynamic therapy.