Analysis of tumor protein in acidic condtion and Development of magnetic hyperthermia for tumor acidic target
Analysis of tumor protein in acidic condtion and Development of magnetic hyperthermia for tumor acidic target
批准号:
23791635
负责人:
ASANUMA Kunihiro
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
mRNA expression and protein production of CAIX(Carbonic Anhydrase)was expressed in tumor cells in acidic condtion. CAIX is thought to be one of the target factor for nanomagnetite and drug deliverly in acidic condition around tumor tissues. Additionally, CAIX inhibitors prevented tumor growth in vivo. These leads to the possibility that antibody angainst functional site of CAIX epitope has synergy effect for nanomagnetite and drug delivery. Furthermore, inhibitory effect of cell proliferation was analized using 320 drugs of compound library. 9 drugs for osteosarcomas and 4 drugs for soft tissue sarcomas were selected. Thses slected drugs may be useful for drug delivery by CAIX targeted liposome.
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DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Satanaka H, Akeda K, Kusuzaki K, Tujii M, Iino T, Uemura T, Nakamura T, Matsubara T, Asanuma K, Matsumine A, Sudo A]
通讯作者:
Sudo A
Analysis of tumor metastatic using low coagulation activity model in mice.
使用小鼠低凝血活性模型分析肿瘤转移。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[K. Asanuma, A. Matsumine, Y. Asanuma, N. Akita, T. Yoshikawa, K. Yoshida, T. Matsubara, T. Nakamura, T. Okamoto, Tatsuya Hayashi, A. Uchida, A. Sudo.]
通讯作者:
A. Sudo.
高知悪性骨軟部腫瘍における腫瘍細胞外pH と予後の検討
高知县恶性骨软组织肿瘤细胞外pH值检测及预后
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[松原孝夫, 楠崎克之, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広]
通讯作者:
須藤啓広
軟部肉腫における診断の遅延が臨床経過に及ぼす影響.
延迟诊断对软组织肉瘤临床病程的影响。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[中村知樹, 松峯昭彦, 松原孝夫, 淺沼邦洋, 渥美覚, 内田淳正, 須藤啓広.]
通讯作者:
須藤啓広.
低悪性度軟骨肉腫の治療成績.
低度软骨肉瘤的治疗结果。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[渥美覚, 松峯昭彦, 淺沼邦洋, 松原孝夫, 中村知樹, 内田淳正, 須藤啓広.]
通讯作者:
須藤啓広.
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