Development of the selective block of nociceptive fiber

我们已经证明，左旋布比卡因，布比卡因的S（-）对映体，产生有效的差异性感觉神经阻滞相比，布比卡因在人类的效果。低浓度左旋布比卡因对C纤维传导的抑制程度大于对Aβ纤维的抑制程度，这可能导致大鼠在不干扰触觉的情况下优先阻滞痛觉。为使左旋布比卡因对感觉神经产生不同的阻滞效应，低浓度和高剂量局麻药的使用可能是有效的。这些结果将在未来为患者带来好处。

We have proved that the levobupivacaine, an S (-) enantiomer of bupivacaine, produced potent differential sensory nerve block compared to the effect of bupivacaine in human. And low concentrations of levobupivacaine suppressedconduction in C fibers to a greater extent than in Aβ fibers, possibly resulting in preferential sensory blocking of the pain sensation without disturbing tactile sensationin rats. T o achieve differential blocking effect on sensory nerves by using levobupivacaine, the use of local anesthetics at low concentrations and high doses might be effective. These results will bring benefits to patient in the future.