The crosstalk pathway between macrophages and T-lymphocytes involves in neuropathic pain

激活的免疫细胞诱导的周围神经炎症参与神经性疼痛的发病机制。我们研究了巨噬细胞和T细胞之间的串扰在神经性疼痛中的作用。巨噬细胞和T淋巴细胞浸润于损伤的坐骨神经，表达共刺激分子GITRL和GITR。抑制相声可减轻神经损伤性神经性疼痛。因此，通过巨噬细胞和T淋巴细胞之间的串扰调节神经炎症在神经性疼痛中起着至关重要的作用。

The activated immune cells-induced peripheral neuroinflammation contributes to the pathogenesis of neuropathic pain. We investigated the involvement of crosstalk between macrophages and T cells in neuropathic pain. Macrophages and T -lymphocytes infiltrated in the injured sciatic nerve, and they expressed GITRL and GITR which are co-stimulatory molecules. The inhibition of crosstalk alleviated nerve injury-induced neuropathic pain. Threfore, the regulation of neuroinflammtion through a crosstalk between macrophages and T -lymphocytes cells plays a crucial role in neuropathic pain.