The relationship between microenvironment and growth of the cellsregulated by EBAG9 in bladder cancer

将小鼠膀胱癌细胞皮下植入Ebag9基因敲除小鼠和对照组小鼠。我们发现Ebag9敲除小鼠产生的肿瘤体积小于对照组小鼠。此外，Ebag9基因敲除小鼠植入肿瘤的T细胞浸润数量增加。我们使用qPCR分析了肿瘤T细胞中免疫相关基因的表达。值得注意的是，Ebag9基因敲除小鼠的肺部肿瘤转移受到抑制。我们推测EBAG9可能通过调节宿主细胞的免疫应答来调节肿瘤的生长和迁移。

Mouse bladder cancer cells were subcutaneously implanted into Ebag9 knockout mice and control mice. We found that tumor volumes generated in Ebag9 knockoutmice were smaller than that of control mice. Furthermore, numbers of T cell infiltration increased in implanted tumors of Ebag9 knockout mice. We analyzed the expression of immune-related genes in the T cells derived from tumors using qPCR. Notably, tumor metastasis in lung was suppressed in Ebag9 knockout mice. We assume that EBAG9 may regulate tumor growth and migration by regulating immune response of host cells.