Interaction between genetic polymorphisms in estrogen metabolism and environmental factors on Japanese endometrial cancer risk

为了评估子宫内膜癌与雌激素代谢基因多态性之间的关系，我们在爱知癌症中心医院流行病学研究计划（HERPACC研究）的基础上进行了一项病例对照研究。我们发现雌激素代谢的遗传多态性与子宫内膜癌风险之间没有显著相关性，这些多态性与当前BMI之间也没有显著的相互作用。

To assess the association between endometrial cancer and genetic polymorphisms in estrogen metabolism, we conducted a case-control study based on the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC study). We found no significant association between genetic polymorphisms in estrogen metabolism and endometrial cancer risk and no significant interaction between these polymorphisms and current BMI.