Candidate gene association study of Menials' disease

梅尼埃病 (MD) 是一种特发性内耳疾病，其特征为波动性感音神经性听力损失 (SNHL)、耳鸣、耳闷感和复发性自发性阵发性旋转性眩晕。梅尼埃病被认为可归因于内淋巴积水（ELH），但内淋巴积水的机制尚不清楚。据报道，鬃毛基因，如水通道或钾离子通道与梅尼埃病有关，但这些报告中分析的患者数量很少。在这项研究中，我们对 200 名梅尼埃病患者和 100 名对照者进行了基因关联研究。在第一次筛选中，我们鉴定了 5 个显着相关的 SNP，但在第二次筛选中，所有这些 SNP 均没有显着相关。

Meniere’s disease (MD) is an idiopathic disorder of the inner ear characterized by fluctuating sensorineural hearing loss (SNHL), tinnitus, aural fullness, and recurrent spontaneous episodic rotational vertigo. Meniere’s disease has been thought to be attributable to endolymphatic hydrops (ELH), but the mechanism of the endolymphatic hydrops was unknown. Mane genes, like water channel or potassium ion channel was reported to associate with Meniere’s disease but there was small amount of patients were analyzed in these reports. In this study, we performed gene association study with 200 Meniere’s disease patients and 100 control. In first screening we identified 5 significantly associated SNPs but all of them did not associate significantly in second screening.