Candidate gene association study of Menials' disease

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Meniere’s disease (MD) is an idiopathic disorder of the inner ear characterized by fluctuating sensorineural hearing loss (SNHL), tinnitus, aural fullness, and recurrent spontaneous episodic rotational vertigo. Meniere’s disease has been thought to be attributable to endolymphatic hydrops (ELH), but the mechanism of the endolymphatic hydrops was unknown. Mane genes, like water channel or potassium ion channel was reported to associate with Meniere’s disease but there was small amount of patients were analyzed in these reports. In this study, we performed gene association study with 200 Meniere’s disease patients and 100 control. In first screening we identified 5 significantly associated SNPs but all of them did not associate significantly in second screening.