Candidate gene association study of Menials' disease

梅尼埃氏病（MD）是一种内耳特发性疾病，其特征是波动感音神经性听力损失（SNHL）、耳鸣、耳廓充溢和复发性自发性发作性旋转性眩晕。梅尼埃病被认为可归因于内淋巴水肿（ELH），但内淋巴水肿的机制尚不清楚。有报道称与梅尼埃病相关的多基因如水通道、钾离子通道等，但在这些报道中分析的患者数量较少。在本研究中，我们对200例梅尼埃病患者和100例对照组进行了基因关联研究。在第一次筛选中，我们发现了5个显著相关的snp，但在第二次筛选中，它们都没有显著相关。

Meniere’s disease (MD) is an idiopathic disorder of the inner ear characterized by fluctuating sensorineural hearing loss (SNHL), tinnitus, aural fullness, and recurrent spontaneous episodic rotational vertigo. Meniere’s disease has been thought to be attributable to endolymphatic hydrops (ELH), but the mechanism of the endolymphatic hydrops was unknown. Mane genes, like water channel or potassium ion channel was reported to associate with Meniere’s disease but there was small amount of patients were analyzed in these reports. In this study, we performed gene association study with 200 Meniere’s disease patients and 100 control. In first screening we identified 5 significantly associated SNPs but all of them did not associate significantly in second screening.