Functional analysis of TRPV1 channels in vestibular system

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TRPV1 is expressed in sensory neurons such as dorsal root ganglia (DRG) and trigeminal ganglia (TG), and are involved in nociception, being activated by nociceptive stimuli. We investigated the expression of TRPV11 in rat VG neurons by RT-PCR, in situ hybridization, immunohistochemistry, and Ca^2+ imaging experiments, and we revealed that TRPV1 is functional as an ion channel and that co-expressed with TRPA1. In summary, our histological and physiological studies reveal that TRPV1 and TRPA1 are expressed in VG neurons. It is suggested that TRPV1 and TRPA1 in VG neurons might participate in vestibular function and/or dysfunction such as vertigo.