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Mucosal immune response associated with NKT cell activation innasopharyx for the development of prospective mucosal vaccine

Mucosal immune response associated with NKT cell activation innasopharyx for the development of prospective mucosal vaccine
与鼻咽部 NKT 细胞激活相关的粘膜免疫反应,用于开发前瞻性粘膜疫苗
批准号:
23791909
负责人:
NODA Kenji
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

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中文摘要
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英文摘要
Specific IgA plays an important role in the elimination of pathogen.In this study, we demonstrated that CD4+T cells expressing P6-specific Th1 and Th2cytokine mRNA, which is important for the induction of the specific S-IgA immune response,were induced after intranasal immunization with P6 and α-GalCer. These findings suggestthat nasal vaccination with P6 and α-GalCer might be an effective regimen for mucosalvaccine.
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会议论文
Th17 cells contribute to nontypeable Haemophilus influenzae-specific protective immunity induced by nasal vaccination with P6 outer membrane protein and alfa-galactosylceramide
Th17 细胞有助于通过鼻部接种 P6 外膜蛋白和α-半乳糖神经酰胺诱导的不可分型流感嗜血杆菌特异性保护性免疫
DOI: --
发表时间: 2011
期刊: Microbiol Immunol
影响因子: 2.6
作者: [Noda K, Kodama S, Umemoto S, Nomi N, Hirano T, Suzuki M]
通讯作者: Suzuki M
Nasal vaccination with α-galactosylceramide induces protective immunity against nontypeable Haemophilus influenzae associated with NKT cell activation in the nasopharynx
α-半乳糖神经酰胺鼻疫苗接种可诱导针对与鼻咽部 NKT 细胞激活相关的不可分型流感嗜血杆菌的保护性免疫
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Noda K, Kodama S, Umemoto S, Nomi N, Hirano T, Suzuki M, Kenji Noda, Noda K]
通讯作者: Noda K
Nasal vaccination with α-galactosylceramide induces protective immunity against nontypeable Haemophilus influenzae associated with NKT cell activation in the nasopharynx.
经鼻接种 α-半乳糖神经酰胺可诱导针对与鼻咽部 NKT 细胞激活相关的不可分型流感嗜血杆菌的保护性免疫。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Noda K, Kodama S, Umemoto S, Nomi N, Hirano T, Suzuki M, Kenji Noda, Noda K, 野田謙二]
通讯作者: 野田謙二