Development of a Hybrid Three-Dimensional Culture Method in Regenerative Medicine

再生医学中混合三维培养方法的发展

• 批准号: 23791917
• 负责人: SUZUKI TERUHISA
• 金额: $ 2.58万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791917/
• 关键词: 移植; 再生医療; 移植・再生医療

Adipose Derived Stem Cells (ASC) and fibroblasts each promote the regeneration of the tracheal epithelial layer. In this study, we created a 3D Architecture of cell layered arrangement (3D-A) in order to simultaneously make use of the strong points of ASC and fibroblasts. Upon grafting of 3D-A into the tracheal injury model of a rat, we were able to confirm the regeneration of a functional tracheal epithelial layer to near its normal morphology in a shorter time than with grafting of ASC or fibroblasts alone. The development of this hybrid 3D culture method seems to be capable of contributing greatly to trachea regenerative medicine.

脂肪源性干细胞（ASC）和成纤维细胞各自促进气管上皮层的再生。在这项研究中，我们创建了细胞分层排列的3D架构（3D-A），以便同时利用ASC和成纤维细胞的优点。在将3D-A移植到大鼠的气管损伤模型中后，我们能够证实功能性气管上皮层的再生在比单独移植ASC或成纤维细胞更短的时间内接近其正常形态。这种混合3D培养方法的发展似乎能够为气管再生医学做出巨大贡献。

项目成果

ヌードラットの頸部皮膚欠損部に対するヒト脂肪由来幹細胞の創傷治癒効果

人脂肪干细胞对裸鼠颈部皮肤缺损的创面愈合作用

• 发表时间: 2012
• 作者: Himi T;Takano K;Ogasawara N;Go M;Kurose M;Koizumi J;Kamekura R;Kondo A;Ohkuni T;Masaki T;Kojima T;Sawada N;Tsutsumi H;鈴木政博
• 通讯作者: 鈴木政博