The neuroprotection for photoreceptor apoptosis via selective antagonist, BBG

视网膜细胞通过依赖于P2X7受体的途径发生凋亡。细胞死亡是通过快速摄入钙进入细胞内而发生的，随之而来的是细胞膜通透性、半胱氨酸天冬氨酸氨基转移酶激活、细胞色素c和AIF转位等凋亡分子信号。P2X7受体基因敲除小鼠在没有P2X7受体的情况下细胞死亡减少。选择性拮抗剂BBG可逆转细胞死亡和随后的分子信号转导。

The retinal cells developed apoptosis via P2X7 receptor dependent pathways. Cell death developed via rapid Ca++ intake into the cells and followed by apoptotic molecular signals such as membrane permeabilization, caspase activation, cytochrome c and AIF translocation. P2X7 receptor knockout mice showed decreased cell death without P2X7 receptor. The cell death and following molecular signal transduction were reversed by selective antagonist, BBG.