Development of a new antioxidant therapy for sepsis using DHLH-Zn, a novel alpha-lipoic acid

使用 DHLH-Zn（一种新型 α-硫辛酸）开发一种治疗脓毒症的新型抗氧化疗法

• 批准号: 23792076
• 负责人: KOGA HIRONORI
• 金额: $ 2.66万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792076/
• 关键词: 抗酸化; 敗血症; ラジカル; 酸化ストレス

We investigated whether Sodium Zinc Histidine Dithiooctanamide (DHLH-Zn), a novel alpha-lipoic acid derivative, had therapeutic effect against sepsis. The results of the present study indicated that DHLH-Zn ameliorated sepsis-induced organ damage by suppression of oxidative stress in rat model. In addition, we tried to clarify the mechanism of antioxidative effect. We attempted to establish the assessment method of oxidative steress in some biotic samples with the use of electron spin resonance (ESR) apparatus. It was hard to measure the oxidative steress directly because of various interfering factors in samples, however, we improved the accuracy of measurement after careful consideration.

我们研究了组氨酸二硫代辛酰胺锌钠（DHLH-Zn），一种新的α-硫辛酸衍生物，是否对脓毒症有治疗作用。本研究结果表明，DHLH锌通过抑制氧化应激减轻脓毒症大鼠器官损伤。此外，我们还试图阐明其抗氧化作用的机制。本文尝试用电子自旋共振（ESR）技术建立生物样品中氧化应激的评价方法。由于样品中存在多种干扰因素，直接测定氧化应激很困难，但经过仔细考虑，我们提高了测定的准确性。