Development of a new antioxidant therapy for sepsis using DHLH-Zn, a novel alpha-lipoic acid

点击翻译按钮获取中文摘要

We investigated whether Sodium Zinc Histidine Dithiooctanamide (DHLH-Zn), a novel alpha-lipoic acid derivative, had therapeutic effect against sepsis. The results of the present study indicated that DHLH-Zn ameliorated sepsis-induced organ damage by suppression of oxidative stress in rat model. In addition, we tried to clarify the mechanism of antioxidative effect. We attempted to establish the assessment method of oxidative steress in some biotic samples with the use of electron spin resonance (ESR) apparatus. It was hard to measure the oxidative steress directly because of various interfering factors in samples, however, we improved the accuracy of measurement after careful consideration.